PHGY 209 Lecture Notes - Lecture 5: Leukopoiesis, Lymphatic System, Haematopoiesis
21 Sep 2017
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Document Summary
Blood functions essential role in maintaining homeostasis: transport, nutritive, respiratory o2, co2, excretory, hormone transport, temperature regulation, acid-base balance, normal ph = 7. 3-7. 45, protective. Comprises both ecf (plasma) and icf (inside blood cells) May be studied in vivo or in vitro. Represents the percent of blood volume occupied by rbcs. If hematocrit is 45%, total blood volume occupied by rbcs is 2. 25l and by plasma 2. 75l. Glucose, amino acids, lipids (cholesterol, phospholipids, triglycerides), oxygen, carbon. Electrophoresis: fractional method based on movement of charged particles along a voltage gradient. Rate of migration is influenced by: number and distribution of charges, mw of each protein. Each protein migrates at its own rate. Liver produces albumin, fibrinogen, a1, a2, beta globulins. Liver: each type of plasma protein has its own synthetic protein. Plasma protein determine the distribution of fluid between the plasma and the isf compartments by controlling transcapillary dynamics.
