PHGY 209 Lecture Notes - Lecture 28: Adaptive Immune System, Antigen, Antigen-Presenting Cell

• School: McGill University
• Department: Physiology
• Course: PHGY 209
• Professor: Ann Wechsler

Document Summary

Need it to initiate the adaptive immune response. Called differently in animals: mouse= h2 complex, human = hla complex. Transplants do not occur in nature: you will reject other people"s body parts and they will reject yours. Two molecular classes: mhc i (hla i) Hla-a, hla-b, hla-c: mhc ii (hla ii) In each class, molecules have 2 chains, alpha and beta. In mhc (hla) i molecules: the chains are markedly different molecular masses, large alpha chain and small beta-2 microglobin chain. In mhc (hla) ii molecules: the alpha and beta chains are almost same size. All normal cells have an (mhc) hla class i antigen: this is what turns of the nk cell. Only 3 cells have class ii hla: dendritic cell, macrophage, b lymphocyte (b cell) They have it because they are the class. Antigen presenting cells: have the capacity to show another cell antigen. Both have grooves for any kind of antigenic fragment.