PHAR 303 Lecture Notes - Lecture 9: Dna Repair, Dna Mismatch Repair, Dna Adduct
15 Feb 2018
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Document Summary
Due to environmental factors and normal processes inside the cell, this occurs at a rate of 10,000 to. Your dna can be damaged by all kind of exposures. It could also be damaged by the things that are present in your body normally, such as reactive oxygen species. Genetic toxicology: the effects of chemical and physical agents on dna and on the genetic processes of living cells. Clastogen: induces chromosomal aberrations, altering the chromosome: can be detected with different techniques. Alkylating agent: covalently bind to a dna base: they are looking for electrons to share because they are. Dna damage electron deficient, so they try to find a dna base to react with them: alkylating agents can be found in chemical warfare and can be used for cancer treatment as well. Apurinic site: occurs a location where a purine base is removed: can also be caused by alkylating agents.
