PHAR 300 Lecture Notes - Lecture 13: Muscle Weakness, Methyl Group, Interleukin 2

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Crf/crh: crf: 41 a. a. peptide, a prohormone, acts on gpcrs in the anterior pituitary to stimulate pomc synthesis, pomc is processed to release acth and beta-lph, pomc can be cleaved to yield many different peptides beta-endorphin, Increases the delivery of cholesterol to the inner mitochondrial mb. Increases transcription of steroidogenic enzymes (e. g. p450 side chain cleavage enzyme cyp11a1) Corticosteroids: aldosterone: mineralocorticoid salt retention, regulates minerals, cortisol: glucocorticoid intermediary metabolism, regulates glucose, fluctuations in serum glucocorticoids, there are changes in glucocorticoid levels throughout the day, very related to activity patterns. Increased glycogenolysis and gluconeogenesis increase blood glucose. Increased lipolysis and lipogenesis increase fat deposits. Increased protein catabolism increase osteoporosis (bone breakdown: anti-inflammatory, generally transcriptional repression (nf-kb inhibition, local and systemic effects, including: Decreased production of prostaglandins, cytokines and interleukins. Decreased proliferation and migration of lymphocytes and macrophages: e. g. Cortisol vs. dexamethasone: adding certain groups to the structure can alter the activity of the drug. Fluoride can increase mineralocorticoid and glucocorticoid activity.