MIMM 413 Lecture : april 2 2012- dr. geary.docx
15 May 2012
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There are more parasites than any other kind of animals. There are 200 or so malaria species, and about 4 infect people. Most hosts restrict most parasites; there is a counter filter. We do not intercept with the parasites, we do not come into counter with it. The other is that we prevent the encounter with the disease. The compatibility filter is that, although we could be infected with some parasites, they do not take. There could be a receptor missing, a nutrient missing, or the innate immune system is good at killing it. Drugs and vaccines do not prevent the infection per se, but they prevent the infection from being more successful. We really only have prophylactic drugs with malaria. It does not prevent infection, it prevents success of infection. Before you can talk about which drug helps for which parasite, you need to have a feel for the drug mechanism itself.
