MIMM 314 Lecture Notes - Lecture 9: Adaptive Immune System, Innate Immune System, Immune Tolerance

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 314
• Professor: Ciro Pgccirillo

Document Summary

Final exam is cumulative: most of exam is post- midterm content, review sessions coming up, course evaluations open, benefits course. Tuesday next week final mystery case. T cell activation + differentiation. "signal 3" usually from inflammatory cytokine (most apc- derived but can also come from non- apc cells) Food is also antigens immune cells don"t activate because tolerogenic context + other regulatory mechanisms. Socs- related families that regulate cytokine responsiveness. While apc provide activating and maturation signals. The t cells provide requisite signals to apcs to activate them too. Stratification of prototypic immune response: establishment of infection. Immunological memory: response to secondary infection, shape of curve will be dramatically different, accelerate, augment, and fine tune response. Vaccination increase pool of cells formed for response. In adaptive immune response (not yet at memory) Features of the majority of effector t cells: death by apoptosis. Dna cleaved will be stepwise if run on gel.