MIMM 314 Lecture Notes - Lecture 8: Adaptive Immune System, Cell-Mediated Immunity, Phase Response

• School: McGill University
• Department: Microbiology & Immunology
• Course: MIMM 314
• Professor: Ciro Pgccirillo

Document Summary

Immune response against a challenge. Y axis magnitude of microbial growth. Anything below blue limit - not enough growth to elicit immune response. X axis duration in the order of days, perhaps even months. Immune response stratified in distinct compartments. 1st phase establishment of infection. Entry depends on microbe: depending on local mechanisms curve will be different. All microbial growth is below threshold. Significant innate components exposed and receive initial signals. Microbial growth surpasses threshold required to activate adaptive response. Important adaptive (t and b) compartments. Optimal t and b activity - peak of microbial growth. 3rd component adaptive immune response. Immunological memory: onset of infection reduced, peak lowered. Diverse mechanisms for dealing with broad range of pathogens. Surveillance apc access antigen. Self- tolerance - minimize response to self. Effector - capacity to maximize effector function - : memory. Local infection - injury: penetration of epithelium, avoid t and b cell response.