MIMM 314 Lecture Notes - Lecture 5: Cd44, Red Blood Cell, Thymocyte
26 Apr 2019
School
Department
Course
Professor
Document Summary
Some stay in the bone marrow and differentiate into b cells. Some travel to thymus to become t cells. They differentiate into: monocytes/macrophages, dendritic cells, granulocytes, erythrocytes, platelets. Will give rise to a variety of different cells: b ell, nk cell. Ilc: also some immature dendritic cells, t cells. Some progenitors will migrate to thymus to differentiate. Some lymphoid progenitors called etp (early t progenitor) Migrate to thymus to differentiate into t cell. Selection of t cells that express tcr able to interact with self mhc molecules needed for its differentiation: positive selection. Elimination of t cells that have too much affinity for self mhc: negative selection. T cell subsets a b t cells g d t cells. Role of thymic stroma in differentiation of precursor cells. Nice with nude mutation - fail to develop a good thymic epithelium: digeorge"s syndrome in humans. In peripheral organs of nude mice, they have no t cells.
