MIMM 214 Lecture Notes - Lecture 31: Acute-Phase Protein, Ctla-4, Regulatory T Cell
4 Apr 2017
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Lymphocyte development, negative regulation & immune tolerance (module 4) The immune response contracts within 10-14 days: after ag is removed, most lymphocytes are no longer required and undergo apoptosis, regulatory t cells may also help to quell responses by releasing inhibitory cytokines. When you first get infected, there is establishment of the infection where you have replication of the organism and then eventually clearance of the organism if the immune response is working appropriately. Once infection has been resolved, you don"t need all these t cells activated or huge secretin of antibody etc. At the end of an immune response and antigen has been cleared from the system, the lymphocytes are no longer needed, so most of them die by apoptosis there is a contraction phase. There are a few other mechanisms that can be involved in regulating immune responses, not necessarily the contraction phase but regulating immune responses in general. Recognition effector regulation memory.
