INDS 212 Lecture Notes - Lecture 50: Belize Dollar, Grapefruit Juice, Rebound Effect

• School: McGill University
• Department: Interndisciplinary Studies
• Course: INDS 212
• Professor: Fraser Moore

Document Summary

If people are addicted to bzds, then you want a longer t/2 because there"s less of a high". For instance, to get people off xanax (bzd w/short half life), you calculate an equivalent dose but to take only once per day. Symptoms can occur upon discontinuation or between doses: addiction: compulsive, out of control use of a drug despite negative consequences. Discontinuation symptoms rebound and withdrawal symptoms more severe with potent, short-acting bzd (alprazolam, lorazepam). Obviate with switch to long-acting bzd like clonazepam: rebound symptoms: return of symptoms (anxiety, insomnia) at greater intensity than original ones. Short lived: full blown withdrawal syndrome: onset 1-4 days, peaks days after onset, then disappears over 1-3 weeks. Symptoms are new (symptoms you"ve never had before): e. g. irritability, insomnia, tremulousness, sweating, anorexia, nausea, diarrhea, abdominal discomfort, lethargy, fatigue, tachycardia, systolic hypertension, delirium, & seizures: relapse: return of original symptoms (anxiety, insomnia, panic).