BIOC 454 Lecture Notes - Lecture 11: Neurotrophin, Haematopoiesis, Caspase
16 Jan 2018
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Document Summary
Occurs by activation of caspases (proteases), which cleave many proteins cell shrinks and segregates into small aggregates. During the development of the worm, an exact number of cells die (131). Upper half of the cartoon the process in c. elegans. Gof in ced3 lead to excessive death, was the most downstream and as responsible for executing the. Ced4 was immediately upstream, overexpression lead to increase in cell death unless ced3 has a disabling mutation. Ced9 was upstream of ced4 and interacts with ced4 and was antideath. In cancer, all oncogenes till now were driving excessive cell proliferation. In lymphoma, a new gene was identified, but it wasn"t driving proliferation. Sequencing revealed that ced9 showed sequence homology to bcl2, the new oncogene related to cell survival. Very quickly, homologs were found in humans: ced3 -> 13 caspases in humans, ced4 -> an adaptor for ced3, driving its activation through proprotein processing and human analog was.
