BIOC 311 Lecture Notes - Lecture 25: Carbamoyl Phosphate Synthetase I, Carbamoyl Phosphate Synthetase, Orotic Aciduria
12 Feb 2020
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Learn what enzymes go where in the cube. Remember: more complicated because we have to make uridine for rna and thymidine for dna. Also, uridylate is the precursor of everything. Important for the cell to only put thymine on deoxyribose: cmp is made from ctp, which is made from utp, dtmp is made from dump (from dutp) Origin of atoms: 2 c"s and 1 n from aspartate, one n from glutamine, 1 c from hco3, thought to be so that the intermediates don"t diffuse out of the cell. Prpp is added at the end (on the contrary to purine pathway) Regulation occurs at the first two steps as well: animals: regulation is at the first step of synthesis (carbamoyl phosphate synthetase ii) Remember: carbamoyl phosphate synthetase i is in the mitochondria. Since carbamoyl phosphate synthase ii is in the cytosol, animals can regulate it: prokaryotes: regulation is at the second step (aspartate transcarbamoylase)
