BINF 511 Lecture 1: BINF 511 Lecture 1 10Jan2018
25 Jun 2018
School
Department
Course
Professor
Lecture 1: Introduction to the course
January 10, 2018
Some course information
BINF 511: Bioinformatics for Genomics
Martina V. Stromvik (Department of Plant Science)
Office hours: Wednesdays 12:30-2:30 pm or by appointment
Class: Wednesdays 8:35-11:25 pm, Macdonald-Stewart building room MS2-028 (Macdonald campus)
Teaching assistant: Maria Kyriakidou ([email protected])
Email Maria with any questions regarding to labs
Midterm will be in class - about an hour; then we will watch a movie afterwards
Final will be scheduled at a later date
Exams are short answers and multiple choice
Communications between computer scientists and life scientists
Genome-based bioinformatics
A part of computational biology
The acquisition, structuring, processing, analysis and storage of all genome-related data
Integration with other knowledge resources
Creation of a context
The first two human beings to be presented with their own genome sequence
Craig Venter (draft 2001)
James Watson (2007)
Genomics strategies and data
Central dogma
oDNA -> RNA -> protein
DNA: the collection of all the genes in an organism is called the genome
Another definition of genome includes all DNA in an organism
To name all genes or Open Reading Frames (ORFs) ORFEOME
RNA: the collection of all the transcripts is called the transcriptome
Protein: the collection of all the gene products is called the proteome
Metabolites: the collection of all the metabolites is called the
metabolome
Types of genomics
Comparative genomics: comparing genomes of different species
oOften a 'model' organism and a more 'important' organism; ex: mouse-human
Functional genomics: study of genome function, typically gene function but also including roles
of other parts of the genome (repeats and polymorphisms)
Structural genomics: focus on genome physical structure and organization
oAlso high-throughput study of protein structure
oIdea: from gene to structure to function
How many genomes in a cell? (aka where is the DNA stored?)
Document Summary
Office hours: wednesdays 12:30-2:30 pm or by appointment. Class: wednesdays 8:35-11:25 pm, macdonald-stewart building room ms2-028 (macdonald campus) Email maria with any questions regarding to labs. Midterm will be in class - about an hour; then we will watch a movie afterwards. Final will be scheduled at a later date. The acquisition, structuring, processing, analysis and storage of all genome-related data. The first two human beings to be presented with their own genome sequence. Central dogma: dna -> rna -> protein. Another definition of genome includes all dna in an organism. To name all genes or open reading frames (orfs) orfeome. Dna: the collection of all the genes in an organism is called the genome. Rna: the collection of all the transcripts is called the transcriptome. Protein: the collection of all the gene products is called the proteome. Metabolites: the collection of all the metabolites is called the metabolome.
