ANAT 322 Lecture Notes - Lecture 12: Colocalization, Ovulation, Anorectic
3 Sep 2016
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Lifestyle change (diet & physical activity), development of drugs. Rimonabant: reduce pleasure sensation when eat (against addictive brain) depression, suicidal thoughts; decreasing pleasure in life as well. But fruit juices more acidic can"t consume the same amount as sodas. But palpability sweet gives more pleasure sensation want to eat more. Obesity not only body weight, but also many diseases. Homeostatic system: increase motivation to eat following depletion of energy stores (like thermostat) Hedonic system: reward-based, activated when eat palatable; hedonic often override homeostatic system obesity. Bottom of brain, multiple nuclei; surrounds 3rd ventricle (where csf) Lesion diff parts of hypothalamus changes in food intake. Db is receptor, ob is ligand circulating reduce food intake normally ob/ob missing a hormone, db/db has a lot of the hormone (overexpress ligand try overcome missing receptor) Treat ob/ob mice w/leptin normalize body weight. Majority of obese patients are normal in both leptin & receptor, just overconsumption of energy. Leptin secreted from adipocytes blood brain.
