ANAT 322 Lecture Notes - Lecture 14: Oligospermia, Cholesterol, Azoospermia

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Principles of hpt axis same as hpg in females. Theca cell produce androgen = leydig cell, respond to lh to make androgen (testosterone) Granulosa cell support oocyte = sertoli cell support spermatagonial stem cells, target of fsh. Lh & fsh together regulate spermatogenesis & steroidogenesis. Testes only makes inhibin b (females have a & b), inhibin regulate pituitary, regulate fsh, not. Mutation in gnrh gene hh, failed to go through puberty. No functional gnrh gene testesterone low, gonadotropins (lh & fsh) low. Measure gnrh secretion at pituitary portal: discrete gnrh pulses lh pulses testosterone pulses. Testosterone has longer half life than gnrh & lh. Loss of ve feedback from previous t pulse as signal. Lesion arcuate nucleus (damage pulse generator) no lh & fsh secretion and lh pulses. Give back exogensous gnrh pulses get endogenous lh pulses back t pulse. Castrated: rapid gnrh pulse rapid lh pulse. Give t back to castrated slower gnrh pulse.

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