ANAT 322 Lecture Notes - Lecture 8: Microglia, Tryptophan, Neutrophil
3 Sep 2016
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Positive symptoms: appear denovo in individuals, not always present, in episodes; not good symptoms. Not in childhood; usually around adolescence after teens. Prenatal genes induced early in development mild social/cognitive deficits & motor function. Full diagnosis only occurs in late teens/early 20s. Stress & social adversity social anxiety, quasi-psychotic ideas. Multi-hit hypothesis: many events during development increase risk of schizophrenia. Scz usually relies on self-reports; study some behaviour/structural/neurochemical effects in offspring, when adult look for scz symptoms. Some of these models may be too strong. Releases many proteins/nucleic acids from cells usually not present in ecf; these elements can also activate tlr (alarm system; endogenous but in wrong place inflammation to clean up) Act same as when inject lps, but this case no lps around body. Activate liver & brain (poa, hpa axis) of mother. Or trigger other responses e. g. non-heme iron drop dramatically during infections (draw nutrients from bacteria)
