ANAT 322 Lecture Notes - Lecture 17: Dentate Gyrus, Cannabinoid, Spatial Memory

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 322
• Professor: David Ragsdale

Document Summary

Pvn secrete crf & avp into hypophysial portal pituitary secrete acth adrenal make gc turn off axis. Lot of crf in other areas of brain outside of pvn, crf as neurotransmitter. Dopaminergic neurons in vta for drug addiction also express crf. Subordinate group: eat more calories than dominant; antagonist suppress eating to level of dominant; Acth peak before active phase large corticosterone (more sensitive to acth) Clock & bmal1 for star (bring cholesterol into mitochondria, for steroidogenesis) Acth receptor pka camp phosphorylate creb protein in nucleus activate star star into mitochondria, where sterodigenesis, bind cholesterol induce cortisol production. Clock genes for regulating star protein for sterodigenesis. Gc suppress acth release at pituitary, suppress crh synthesis/release at pvn, affect neurons projecting to pvn neurons (e. g. hippocampus) Adx (remove gc feedback) high crf mrna in pvn. Replace gc suppress crf mrna (large drop w/increasing gc dose) Adx more crf in external zone of median eminence. Adx increase crh & acth, thyroid weight.