ANAT 322 Lecture Notes - Lecture 6: Kisspeptin, Theca, Adenylyl Cyclase

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 322
• Professor: David Ragsdale

Document Summary

Global era ko: expected loss of ve feedback, but this doesn"t tell where lost. Ko era in gonadotropes: low lh, no ve feedback of estrogen at pituitary; all estrogen feedback at brain (mostly kiss in arc) Ko era at pituitary: some ko mice infertile, some ko maintain some fertility. Both subfertile & fertile ko had increases in lh is ve feedback at pituitary. Can"t conclude if estrogen has ve feedback at pituitary. Both groups had infertility in er ko mice loss of+ve feedback. Only 2nd group looked at lh surge generation. Suggests estrogen does have +ve effect on pituitary. Kallman"s syndrome: don"t go through puberty because gnrh neurons fail to migrate to brain during development. Gave gnrh in pulses to kallman"s patient normal menstrual cycle. First given: huge increase in lh & fsh (not used to), but then higher than in previous. Lh surge, but no gnrh surge (because removed +ve feedback in brain)