ANAT 262 Lecture Notes - Lecture 19: Coiled Coil, Intermediate Filament, Lamin

• School: McGill University
• Department: Anatomy & Cell Biology
• Course: ANAT 262
• Professor: John Presley

Document Summary

Lecture 19: intermediate filaments lundi 21 mars 2016. Catastrophe: describes the transition of a mt end from growing to shrinking state. Rescue: transition of a mt end from shrinking to growing state. Treadmiling: polymerization involving mts with a free + end and a free - minus end or an. Af with a free + end and free - end, addition to plus end is equal to loss at - end (- end not attached) Kinesin 14 makes the anti-parallel bipolar filaments connect, more linking than pulling apart, conventional. Involves moving apart the two spindles by: (1) elongation of the polar mts at the + end and with the action of krp (bimc) and (2) motor proteins acting in conjugation with astral. Fimbrin, alpha-actinin and filmain are 3 proteins that crosslink af in different ways. Fimbrin and a-actinin are reffered to as af bundling proteins and crosslink af to form parallel arrays or bundles.