ANAT 262 Lecture Notes - Lecture 8: Nuclear Localization Sequence, Nuclear Export Signal, Nuclear Pore
15 Jul 2016
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Knock out lamin a in mice: alive for approximately 3 weeks since lamin b can compensate in part of lamin a. Mediate trafficking between nucleus and cytosol through active transport and diffusion. In order to diffuse, the molecule has to be smaller than 40 kda, and requires a concentration gradient. The central channel cannot accommodate molecules larger than. Nuclear porins are organized into modules (large sub-structures) modules are produced during mitosis. Hence, npc is disassemble into those different modules, and come back together at the end of mitosis to reform npc. Filaments of the central gated channel: structures are generated by fg repeats. Form: oily spaghetti model: forming theses filament in the central gated channel. Hydrogel model: where the repeats are organized in a stiffer fashion or forming a lattice. Filaments coming from fxf repeats are inside central gated channel, and if you have filaments floating around it can cause problems with diffusion.
