CHEM 181 Lecture 22: chem 22

• School: McGill University
• Department: Chemistry
• Course: CHEM 181
• Professor: Joe Schwarcz

Document Summary

Ex: used in moscow [oct 31, 2002] = chechen rebels took over theatre of 850 people & stand-off. Ended with fentanyl in ventilation system = 170 died *including 39 of the rebels. *half-life = #hours for half to be metabolized in body. Morphine = potency of 1 & half-life of 2h. *all opioid = 1 benzene ring + 2 carbons + 1 nitrogen so fentanyl & morphine = simple molecules. Similar general appearance = similar capacities so morphine can be easily modified. Fentanyl = potency of 100x morphine & half-life of 5h. Death from fentanyl overdose [more than # death by car accident] in montreal = concerned over presence of deadly drug. National centers for health statistics estimate drug overdose. Killed 64 000 people in us last year - rise 21% from 2015. Equal to population of sarnia, ontario chateauguay, quebec. 7 deaths/hour in us due to fentanyl abuse. Ex: 1st fentanyl sublingual spray for cancer pain patients subsys.