BIOL 201 Lecture Notes - Lecture 12: Mitochondrion, Ion, Q Cycle
26 Jan 2016
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Catalyzes transfer of electrons from nadh to coq. 1 flavin (fmn), 8 fe-s: connected to one sugar, picks up 2 electrons from nadh and 2 protons from the mitochondrial matrix to form fmnh2. Nadh + coq + 6h+ in + coqh2 + 4h+ 3 subunits show similarity to cation transporters. There is a long helix that runs parallel to the membrane and. Nad+ + h+ in out crosses all the subunits. As the electrons move from one carrier to the next, they trigger conformational changes which results in the pumping of the protons from the matrix to the intermembrane space. Contains succinate dehydrogenase of citric acid cycle. Succinate + coq fumarate + coqh2: succinate has 2 more hs than fumarate. Coqh2-cytochrome c reductase (complex iii) cytochrome b/c1 complex. Mobile qh2 diffuses through membrane to complex iii: complex iii catalyzes the transfer of electrons from qh2 to cytochrome c. Cytochrome c: a small, mobile, h2o soluble, + charged electron carrier.
