BIOL 115 Lecture Notes - Lecture 7: R.W.D. Molenbeek, Gene, Epistasis
25 Jun 2016
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Document Summary
The number of genes: polygenic or multigenic traits - multiple genes may contribute to a trait, eg at least six genes affect the risk of heart attack, epitstasis, the complex interaction between genes, eg coat colour in mice. The interactiong between the agouti (brown) and albino loci, get a variation. Colorless chemical (albino) pigment (agouti) pigment binding: epistasis often results from genes involved in different steps of the same process or pathway. Wanted to purify a gene: needed a method of isolating cell compounds (fairly simple, an assay for genetic materialness the determination of the amount of a particular constituent of a mixture eg pricking allergy test. Infected bacteria produced virus that contained 32p and almost no 35 s, it followed p-containing dna must be the viral genetic material: dna = genetic material. How dna works as genetic material watson and crick had to find structure. The specific structure of monomers: a, t, c, g, linked as polymer, chargoff"s rules.
