BIOL 102 Lecture Notes - Lecture 10: Untranslated Region, Alternative Splicing, Rna Interference
25 Jun 2016
School
Department
Course
Professor
Document Summary
Inactive x chromosomes become barr bodies: euchromatin o lightly stained, less condensed, transcriptionally active, heterochromatin o darkly stained, more condensed , transcriptionally inactive, post transcriptional mechanisms of gene regulation o alternative splicing. Can make different proteins depending on which exons are left and which are spliced out o during splicing, the order of exons in the mrna is the same as their order in the chromosomes: rna stability o cells possess mrnas in ways that affect their stability o stability of specific mrna is a function of its unique 5 prime and 3 prime untranslated. Region (utr) o cells have specific mechanisms for recognizing and regulating specific mrna: mrna is like water in a reservoir o the rate of inflow (transcription) and the rate of outflow (degradation) determine the water (or mrna) level, translational control o affects the ability of mrnas to be translated by the ribosome o rna interference.
