PSYC-2606EL Lecture Notes - Lecture 6: Ipsapirone, Raphe Nuclei, Limbic System
1 Nov 2016
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Ach receptors: nicotinic ach receptors are found at synapses on muscles and in autonomic ganglia, blockade of these receptors is responsible for the paralysis caused by curare and bungarotoxin, control channels in two ways: Example: acetylcholinesterase (ache: reuptake transmitter is taken up into the presynaptic cell, transporters are special presynaptic cells used in reuptake. Exaggerates the effect of the ligand binds to receptor: an antagonist blocks the receptor from being activated by other ligands. Stops or reduces the normal neurotransmitter to activate: an inverse agonist initiates an effect that is the opposite of the normal function, gabaa receptor (calms you down, agonist: benzodiazepine (sedative, antagonist: flumazepil (reduce sedation) Irreversible antagonist cause long lasting irreversible effects. (naloxazone - - receptor) Key neurotransmitters: dopamine (da) is found in neurons in: the mesostriatal pathway originates in the midbrain, specifically the substantia nigra and innervates the striatum. This pathway is important in motor control and neuronal loss is a cause of.
