PHYL 3520 Lecture Notes - Lecture 21: Body Mass Index, Cystic Fibrosis, Chest Physiotherapy
3 Apr 2020
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Phyl 3520 lecture 21 march 11, 2020 intro to cf case and airway epithelium. Cf is progressive and rare worldwide but is the most common genetic respiratory disease in north. Cf is autosomal recessive genetic mutation and is under the newborn screening protocol (established 2 years ago). Pseudomonas aeruginosa: abnormalities in chest x-ray, airways obstruction. This is a disease that affects multiple organs. Any tissues that express the cftr gene involved would have a mutation. Changes in the epithelium would affect the respiration. The cf patient suffer chronic lung disease, which affect breathing capacity with frequent infections and mucous buildup. Malnutrition as an effect of the pancrease and intestine would also contribute to the early deaths in cf patients. The cf patient needs an average of 2-3 hours a day of intense treatment. Discovery of the cystic fibrosis transmembrane conductance regulator gene: cystic fibrosis (cf) is inherited in an autosomal recessive manner.
