CH&E 4010 Lecture Notes - Lecture 19: Relative Risk, Statistical Significance, Prospective Cohort Study

• School: Dalhousie University
• Department: Community Health&Epidemiology
• Course: CH&E 4010
• Professor: Leslie Campbell

Document Summary

Ch&e 4010 lecture 18 march 17, 2021 critical appraisal ii: breast cancer and hormone-replacement. Objectives: apply the principles of critical appraisal to an epidemiologic research paper. High estrogen concentration leads to higher cell proliferation: estrogen increases breast density and decreases sensitivity of mammograms. So, this means that estrogen treatment leads to a lesser likelihood of detecting the breast cancer. The siize of the cohort is really large and knowing the study design would be led to a lot of faith. The lancet is also a highly reputable journal. Judging by the media coverage as well, this is a highly impactful paper. Yes: what question(s) did the authors set out to answer, the million women study was set up chiefly to investigate the relation between various patterns of use of hrt and breast cancer incidence and mortality. Investigate the relationship between various patterns of use of hrt and: breast cancer incidence, breast cancer mortality.