BIOL 2040 Lecture Notes - Lecture 1: Immune System, Drug Resistance, Mutation
15 Jan 2018
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Lecture #1: divergence, different populations occur in different places and under different ecological conditions, populations in different places tend not to mate with one another. It is difficult to be well adapted to all sets of conditions: populations will each adapt to their separate conditions, population will thus become different from one another, variation occurs before selection, selection filters variation that occurs. Inserted into host dna: parasites host"s cellular machinery to reproduce new virus. Lecture #1: evolution to avoid the host"s immune response. Limited divergence: similar across multiple hiv strains. Lecture #1: prevent evolution of drug resistance, treat multiple drug cocktails to patient, virions must evolve resistance to many drugs at the same time. Ideally it would be: impossible for one virion to be resistant to all drugs in cocktails. 11/01/18: virulence to t-cells, ccr5 - initial infection attacks these, but as the t-cells with ccr5 get used up, selection favors virions that use: cxcr4.
