PSYC 455 Lecture Notes - Lecture 13: Generalized Anxiety Disorder, Allostatic Load, Hans Selye
26 Apr 2018
School
Department
Course
Professor
PSYC 455
Lecture 13 – Generalized Anxiety Disorder
• Anxiolytics
1. Recall:
a. Act on the GABAA receptor
b. Proscribed for insomnia
c. Problem:
- Addiction potential
- Dangerous when mixed with alcohol
- Impair memory
d. Example:
- Benzodiazepine
- Valium
2. Newer version of Benzodiazepines:
a. Positive Allosteric Modulators:
- PAM:
i. Positive:
Activate GABAA receptor
ii. Allosteric:
Bind to the allosteric binding site
iii. Modulators:
Modulate themselves
- Three types:
i. Full allosteric modulators (most dangerous/highest abuse potential;
e.g., Xanax):
Act with high potency and efficacy on many GABAA receptors
ii. Selective allosteric modulator (e.g., Valium):
Act with high potency and efficacy but only on a select number of
the GABAA receptors
iii. Partial allosteric modulators (safest; e.g., Ambien):
Act with high potency but low efficacy
• Fear vs. Anxiety vs. Stress
1. Anxiety:
a. Thinking about going to the dentist
2. Fear:
a. Beig i the detist’s hair
3. Stress:
a. Our bodies response to something pushing against homeostasis
b. Allostatic load:
- It’s the oiatio of stress, poor diet, ad iatiity that akes stress
destructive and cause our modern-day illnesses
• Stress
1. Hans Selye (The Stressors of Life):
a. Stressors (i.e. something that forces us to have a stress response):
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Lecture 13 generalized anxiety disorder: anxiolytics, recall, act on the gabaa receptor, proscribed for insomnia, problem: Valium: newer version of benzodiazepines, positive allosteric modulators: Full allosteric modulators (most dangerous/highest abuse potential; e. g. , xanax): Act with high potency and efficacy on many gabaa receptors. Act with high potency and efficacy but only on a select number of the gabaa receptors. Act with high potency but low efficacy: fear vs. anxiety vs. Stress: anxiety, thinking about going to the dentist, fear, bei(cid:374)g i(cid:374) the de(cid:374)tist"s (cid:272)hair, stress, our bodies response to something pushing against homeostasis, allostatic load: It"s the (cid:272)o(cid:373)(cid:271)i(cid:374)atio(cid:374) of stress, poor diet, a(cid:374)d i(cid:374)a(cid:272)ti(cid:448)ity that (cid:373)akes stress destructive and cause our modern-day illnesses: stress, hans selye (the stressors of life), stressors (i. e. something that forces us to have a stress response): After they out run the lion, they go back to grazing (i. e. their stress response goes up only when they need it) Psychological (e. g. , stressors, rent, fight with girlfriend):
