PSYC 455 Lecture Notes - Lecture 16: Vesicular Monoamine Transporter, Catecholamine, Antiporter
26 Apr 2018
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PSYC 455
Lecture 16 – Catecholamine (Monoamines Continued)
• Monoamines (Continued)
1. Dopamine:
a. DA transportation to the Synapse:
- VMAT (i.e. Vesicular Monoamine Transporter):
i. DA gets put into the vesicles by a transported (i.e. the VMAT):
The VMAT sits on the vesicle and is driven by a proton antiporter
(i.e. uses ATP to pump H+ ions into the vesicle):
VMAT can then pump DA into the vesicle, while pumping H+
out
ii. Is there a VMAT for norepinephrine and epinephrine?
No because DA is converted to these two within the vesicle.
2. Monoamine Transporters:
a. Include:
- DAT (Dopamine Transporter):
i. Small amount found in the PFC
- NET (Norepinephrine Transporter):
i. More foud i the PFC e are’t sure hy
- SERT (Serotonin Transporter)
b. The ooaies use eah other’s transporters (e.g., Dopamine has a higher
affinity for the NET than the DAT)
3. Amphetamines vs. Cocaine:
a. Amphetamines:
- Act on the DA system by filling the dopamine synapses with dopamine (which
is ipulse idepedet; i.e. the euro does’t hae to e firig for the
dopamine to flood into the synapse):
i. This is done by:
Reversing the VMAT (i.e. pump dopamine back into the synapse)
Reversing the DAT (i.e. the DA goes back into the synapse)
b. Cocaine:
- Blocks the DAT
- Impulsive dependent (so context dependent; your high depends on where
you are and if you neurons are firing)
4. Mesocorticolimbic Pathway:
a. DA neurons in the VTA project to:
- The N. Acc (Ventral Striatum):
i. The pathway from the VTA to N. Acc is responsible for the liking of
the addictive properties of drugs
- The PFC
i. Last part of brain to develop (i.e. that’s hy we are all kind of
hyperactive):
Important for:
Executive function (attention, working memory)
ii. Sends reciprocal connections down to the N. Acc that are inhibitory
connection:
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Lecture 16 catecholamine (monoamines continued: monoamines (continued, dopamine, da transportation to the synapse: Da gets put into the vesicles by a transported (i. e. the vmat): The vmat sits on the vesicle and is driven by a proton antiporter (i. e. uses atp to pump h+ ions into the vesicle): Vmat can then pump da into the vesicle, while pumping h+ out. No because da is converted to these two within the vesicle: monoamine transporters, include: More fou(cid:374)d i(cid:374) the pfc (cid:894)(cid:449)e are(cid:374)"t sure (cid:449)hy(cid:895) Sert (serotonin transporter: the (cid:373)o(cid:374)oa(cid:373)i(cid:374)es use ea(cid:272)h other"s transporters (e. g. , dopamine has a higher affinity for the net than the dat, amphetamines vs. Act on the da system by filling the dopamine synapses with dopamine (which is i(cid:373)pulse i(cid:374)depe(cid:374)de(cid:374)t; i. e. the (cid:374)euro(cid:374) does(cid:374)"t ha(cid:448)e to (cid:271)e firi(cid:374)g for the dopamine to flood into the synapse): Reversing the vmat (i. e. pump dopamine back into the synapse) Reversing the dat (i. e. the da goes back into the synapse: cocaine:
