NEUR 3204 Lecture Notes - Lecture 3: Dendritic Spine, Axoplasmic Transport, Autoreceptor

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 3204
• Professor: Matthew Holahan

Document Summary

Lecture 2: much of chemical transmission happens from presynaptic terminal to dendritic spine. If there is enough release, the chance that it will diffuse across synaptic gap is greater: action potential it reaches axon collateral and initiates neurotransmission. Those chemicals/proteins that are at axon collaterals are auto-receptors. D2/ 5-ht receptor on axon collateral (also have them on spines). On presynaptic terminals, you can have the same receptors as postsynaptic spines. Probably due to a tag on synaptic receptors during transcription that sends receptors from golgi to either pre or post synaptic neuron. So, yes there is a lot of electrical activity happening, but in this class we focus on vesicles that cross synaptic cleft and bind on receptors. Thinking about transcription/translation you have dna turning into mrna, then it travels out of the nucleus to mitochondria, gets translated into proteins, then goes to golgi apparatus and gets packed into vesicles. Since receptors are proteins they go through this process.