NEUR 2201 Lecture Notes - Lecture 18: Synaptotagmin 1, Synaptobrevin, Munc-18
2 Jan 2019
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Document Summary
Vesicle-membrane proteins contain: (v)snare protein synaptobrevin: ca++ sensor synaptotagmin (t)snare proteins, syntaxin and snap-25 are anchored to the nerve terminal (active zone, syntaxin is held in native (open) conformation by munc-18. When ca++ comes in (first wave) with. Syntaxin enters open configuration and forms quaternary structure with synaptobrevin and snap-25. When the second wave of ca++ comes in. Ca++ binds to synaptotagmin which binds to the snare complex. Complexin is displaced and a pore is formed. Docking, priming and fusion and the contributing proteins. Lecture 18 ligand- activated ionotropic postsynaptic receptors (chapter 5 (78-86) and 11) Identify the structure of the neuromuscular junction (nmj) and receptor distribution. Describe the physical structure and folding properties of the nachr and the activation properties. Identify and describe the main structural features of the ampa and gaba receptors with respect to direct excitatory and inhibitory properties. At electrical synapses, current flows directly from one neuron to another through gap junction.
