BIOL 3P30 Lecture Notes - Lecture 39: Mtor Inhibitors, Immunosuppression, Laboratory Mouse
25 Aug 2015
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Daf-2 = igf-1 receptor (insulin-like growth factor 1) Produced in various tissues; liver most important in mammals. To achieve a lifespan extension from a daf-2 knock down daf-16 is required. Regulates transcription of genes involved in metabolism, cell growth & proliferation, When phosphorylated by pkb/akt (high igf-1 & therefore high energy status) daf- With reduced igf-1 signalling daf-16 not phosphorylated, goes to nucleus and stimulates transcriptional program slowing metabolic processes and cellular stress resistance. Need to be kept warm and then they live longer. No good data on lifespan but resistant to diabetes and cancer. Igf-1 signaling is an evolutionarily conserved pathway for energy sensing that regulates cell physiology and modulates lifespan mtor (mammalian target of rapamycin) Inhibits cell growth & proliferation treatment, in cancer. Important for building of things for new cells. Ampk inhibits mtor (present during low energy states) 1) o inhibits autophagy increased synthesis of ribosomes stimulation of proteins associated with translation (e. g. ribosomal s6 kinase mtor.
