BIOL 3P30 Lecture Notes - Lecture 38: Calmodulin, Tfam, Catabolism
25 Aug 2015
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Document Summary
In pcg-1 alpha ko cells uncoupling (fccp) is lethal. Inability to recover [atp] in uncoupled pgc-1 alpha ko cells. Increased metabolic demand stimulates pgc-1 alpha activity & synthesis pgc-1 alpha stimulates nrf1/2, tfam, other tf"s increased production of metabolic machinery (mitochondria) sustainable increase of cell metabolic rate recovery of [atp] (and or temperature. Amp kinase as an activator of pgc-1 gene expression p38 map kinase. Adenylate kinase is the enzyme that is over the double arrow. [amp] much more variable than the others, makes it a better signal. Amp kinase is a protein kinase that is highly sensitive to [amp] regulation. A decrease by 1mm may be hard to detect but it will shift the equilibrium all the way to amp so that can be detected. Ampk stimulates aty synthesis (catabolic) pathways and inhibits atp usage (anabolic pathways) Pgc-1 alpha expression and activity mitochondrial biogenesis and other catabolic pathways recovery of atp homeostasis (or temperature in bat)
