BIOL 3P30 Lecture Notes - Lecture 36: Cyclic Adenosine Monophosphate, Decarboxylation, Cytosol
22 Aug 2015
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Remember this is happening at around the mito membrane. So proton gradient is maintained nadh and fadh build up. Cyt c [red] is not taken to cyt c oxidase (rate determining step!) and so no ox/phos. No atp synthesis is happening, what does it mean for cac: no actyl-coa oxidation. Why: aketoglurate dehydrogeanse is inhibited by high atp, isocitrate dehydrogeanse is activated by high adp, nadh/nad ratio is high-> electrons don"t enter etc. Pyruvate dehydrogeanse, citrate synthase, and isocitrate dehydrogeanse are all inhibited. We got lots of acetylcoa, we don"t need it for atp synthesis, let"s store that in fats! Once you use that fat, you can make lots of atp. Acetylcoa is impermeable to the membrane and no carrier protein exists for it! Atp-citrate lyase needs to use atp to generate the thioester bond. Synthesis of fatty acid: we have compartments so we don"t have to change conditions all the time.
