BIOL 1F90 Lecture Notes - Lecture 14: Succinic Acid, Phosphofructokinase, Oxaloacetic Acid

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During the oxidation of some organic molecules (e. g. glucose), nad+ is reduced to nadh: nad+ = nicotinamide adenine dinucleotide, combines with two electrons and h+ to form nadh. Cells use nadh in two ways: oxidation to nad+ for synthesis of atp. Highly exergonic: donation of electrons to organic molecules to energize them. Energized molecules more readily form covalent bonds. Used in anabolic reactions to synthesize large molecules. Reduced because it loses a double bond. Make larger molecules and macromolecules from smaller precursors: = biosynthetic reactions. Also used in synthesis of small organic molecules that are not readily available from food sources. A typical cell uses millions of atp molecules per second. Humans hydrolyze ~45 kg of atp per day! We don"t a(cid:272)tually have (cid:1005)(cid:1004)(cid:1004)l(cid:271)s of atp: each atp undergoes about 10,000 cycles of hydrolysis and resynthesis from adp and pi. 20 to 25% of all proteins bind atp. Motor proteins chaperones= help move things out or between the cells.

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