BIOL 1F25 Lecture Notes - Lecture 15: Long-Term Potentiation, Neocortex, Cyclic Adenosine Monophosphate
28 Mar 2016
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Document Summary
Post-synapic changes: more glutamate receptors put into membrane (ampa type). Both these efects lead to increase in synapic strength that can last for many hours (i. e. , long term poteniaion of synapse). Longer term changes: ca/calmodulin acivates camp messenger pathway: acivates creb (cyclic amp response element binding protein, acivates genes to produce long term efects. Acivaion of genes (nucleus) and new proteins needed. Learning and memory: ltp: increased strength of exising synapses, formaion of new synapses (increased number of synapses), new dendriic spines formed. Spine: locaion of a synapse on the dendrite. Important consideraions for the role of ltp in learning and memory: Problems with involvement of synapic changes in long-term memory formaions: Diferent areas of brain involved in formaion vs storage (studies of h. m. ) Memory reacivaion might lead to further changes in those synapses, which might eventually lead to memory erosion. Theory: factual memories iniially dependent on hippocampus, are eventually consolidated in the neocortex.
