BIOL 1F25 Lecture Notes - Lecture 8: Wicket-Keeper, Methyl Benzoate, Biosensor
13 Feb 2017
School
Department
Course
Professor
Document Summary
Role in fosb transcription factor in nac. C-fos induced in nac by acute cocaine use, put protiens unstable and levels return to normal within 8-12 hours. Chronic cocaine induced a novel fos protein. Fosb in nac very stable - fosb induced in. Nac by many drugs of abuse and non-drug rewards. Increased sensitivity to rewarding effects of cocaine, increased cocaine self- administration. stability of fosb may drive behavioral changes for weeks/ months. maintains state of addiction. Mechanism of permanent plastic change in brain. Changes in fosb not long lived enough to account for life long addictions. Hypothesis: structural changes in neurons of reward pathways are responsible behavioral changes. Chronic cocaine use: increase in number of dendrites of nac neurons persist for months. But no current direct evident that increased number of dendrites underlie long-lived. Analogous to learning and memory field difficult to associate cellular. Ltp (l and m) and chronic cocaine: camp and creb in brain cells.
