BIOL 1123 Lecture Notes - Lecture 25: Hox Gene, Gremlin, Bone Morphogenetic Protein 4

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It compares the development of different organisms in an attempt to understand ancestral relationships between organisms and the developmental mechanisms that bring about evolutionary change. These genes are very important in the development to the phenotypes of individuals. They are key players in the evolution of many types of traits. Example 1: webbed feet in ducks vs. unwebbed feet in chicks. Due to the different expressions of cell-signaling proteins in limbs. It causes the cells to undergo apoptosis and die. Gremlin inhibits the function of bmp4 and allows cells to survive. In the chicken limb, gremlin is expressed throughout the limb except for the area in between the digits so this area dies and creates unwebbed feet. In the case of a duck, gremlin is expressed throughout the entire limb and this results in a webbed foot.

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