PHYL3002 Lecture Notes - Sex Steroid, Human Chorionic Gonadotropin, Pituitary Gland
Document Summary
Can act as a transcription factor (changing function) Lh with bind to its receptor in the leydig cell and have second messenger activation which will lead to the steroid hormone synthesis pathway. Proteins: gonadotrophins: stimulate the gonads, all have an alpha and beta chain (all the same alpha chain but different beta chains) Proteins: somatomammotrophins: tissue growth and function, prolactin anterior pituitary. Large single polypeptide chains (191 199 amino acids: support lactations, mammary gland (lactation, hyperprolacinaemia suppresses fertility. Proteins: cytokines: polypeptides with one or two chains, grouped into families on basis of molecular structure and functions. Inhibin: (granulosa cells, sertoli cells) intra-ovarian and intra-testicular activity, gonad- pituitary interactions (feedback mechanisms on pituitary) Determinants of hormone actions: transport, blood concentration, secretion patterns, receptor expression (can"t achieve its actions unless it can bind to its specific receptor, transport ratio between bound and unbound.
