IMED3004 Lecture Notes - Lecture 4: Peripheral Artery Disease, Histology, Edema
1 Nov 2020
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Acute superficial infection of the skin: most common bacterial skin infection of childhood. Adults can also be affected: athletes, military. Predisposing factors: minor trauma, nasal carriage of staph, organism is often staphylococcus aureus (esp. in bullous subtype) Staphylococcus aureus may produce exfoliative toxins (staphylococcal scalded skin)- a different scenario. Caused by an exotoxin which results in keratinocytes falling apart and blister formation. Subcorneal (i. e. under the stratum corneum) collection of neutrophils. Can see more neutrophils migrating upwards through the epidermis. Surface crust of serum and dying neutrophils: may see bacterial colonies. Typically affects the superficial part of the hair follicle, called the infundibulum": may be related to bacterial infection (e. g. staphylococcus aureus) Can be due to other bacteria, fungi, viruses. Rarely other sterile (e. g. drug reaction: neutrophils in infundibulum. A deeper infectious inflammatory process centred on the pilosebaceous unit. Begins as a painful papule with surrounding erythema (redness) and swelling. The centre becomes soft, yellow and may discharge pus.
