IMED3001 Lecture Notes - Lecture 14: Ace Inhibitor, Juxtaglomerular Apparatus, Perindopril
26 Mar 2020
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Irbesartan: anything else ending in sartan, more specfic than ace inhibitors. Major adverse effects (ae) of ace inhibitors & Irritating dry cough: angioeodema (sudden, locally restricted tissue oedema) Loss of catacholamine-dependent cardiac contractility in compensated heart failure decompensation: use of 1-adrenoceptor blockade in stable heart failure, 1-adrenoceptor blockers imperfectly specific, partial blockade of lung 2- adrenoceptors in asthmatic patients, precipitation of asthma attack. Transudation of fluid from capillaries to tissue. Antiarrhythmic drugs: ca channel affects senile membrane potenials ca can acts as intrcellular ca molecules, graded and arrivals of signals of ca due to high. Loss of ca- dependent contractility in compensated heart failure decompensation. Constipation (verapamil: peripheral-acting ca channel blockers. Ae shared by all peripheral vasodilators: dependent oedema. Dihydropyridines: reduce vascular resistance, nifedipine, felodipine, amlodipine, both: diltiazem, more for general use, adverse effects, ae shared by all antihypertensives: excessive lowering of bp.
