ANHB3323 Lecture Notes - Lecture 22: Cell Culture, Homeostasis

78 views1 pages

3 Jun 2018

School

Department

Course

Professor

For unlimited access to Class Notes, a Class+ subscription is required.

LECTURE TWENTYTWO: Lab on a Chip

Organ on a Chip:

• Term for devices that integrate laboratory functions on a single chip

• Capable of handling extremely small fluids volumes

• Subset of MEMS devices

Advantages:

• Extended capabilities of cell culture

• Mimic complex structure, microenvironment and physiological function

of human organs

• Low cost alternatives to animal/clinical studies

• Increase success rate and speed of drug development

• Low fluid volume used

• More defined/specific mimicry of different tissues

• More analysis per volume → faster assays

• Better control over whole process

• Easier to modify specific conditions

• More data to support human clinical trial

Limitations:

• Finding common cell medium for all organs

• Limited self-renewing potential

• Technology is still new

• Maintaining homeostasis

• Long term nutrition

• Never perfect as a whole system

• Not fully developed yet

• Never reaching complexity the tissues represent

• Detection principles may not always scale down in a positive way

find more resources at oneclass.com

Unlock document

This preview shows half of the first page of the document.
Unlock all 1 pages and 3 million more documents.

Already have an account? Log in

Get access