300884 Lecture Notes - Lecture 29: Central Nervous System, Aseptic Meningitis, Dengue Fever
24 Feb 2020
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Document Summary
Most nsaids penetrate poorly into the central nervous system (cns). However, the cox enzymes are expressed constitutively in some areas of the cns, meaning that even limited penetration may cause adverse effects such as somnolence and dizziness. Nsaids may increase the risk of bleeding in patients with. For this reason, nsaids are only available with a prescription in india. In very rare cases, ibuprofen can cause aseptic meningitis. As with other drugs, allergies to nsaids might exist. While many allergies are specific to one nsaid, up to 1 in 5 people may have unpredictable cross-reactive allergic responses to other nsaids as well. Nsaids reduce kidney blood flow and thereby decrease the efficacy of diuretics , and inhibit the elimination of lithium and methotrexate. Nsaids cause decreased ability to form blood clots, which can increase the risk of bleeding when combined with other drugs that also decrease blood clotting, such as warfarin.
