300884 Lecture Notes - Lecture 8: Acetylcholinesterase Inhibitor, Inositol Trisphosphate, Nicotinic Acetylcholine Receptor
27 Feb 2019
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Document Summary
Enzyme induction is a mechanism of drug interaction. Some drugs increase the activity of other drugs and increase the rate of removal and thus decreasing their effectiveness. Alcohol in regular use, antibiotic rifampicin (used mainly for tuberculosis) Some drugs can inhibit enzymes leading to an accumulation of other drugs in the body and as a result increase their concentrations potentially toxic. Cholinergic receptors: nicotinic receptors; couple to na+ channel excitatory postsynaptic potential depolarization cell activation. Mainly found in autonomic ganglia including the adrenal gland and neuromuscular junctions. Another cholinergic receptor: muscarinic receptor; g protein coupled by and may work by stimulating the formation of inositol triphosphate and by reducing the concentration of camp. M1 receptors; stimulate gastric acid production and in. M2 receptors; decrease cardiac rate & force of contraction. M3 receptors; increase glandular secretion and contraction of visceral smooth muscle. In muscarinic: m1, m2, m3= neural, cardiac, glandular. Acetylcholine receptor agonists: directly and indirectly acting a. r. a.
