300850 Lecture Notes - Lecture 1: Endothelial Activation, Mast Cell, Leukocyte Extravasation
Document Summary
This is an active process (emigration), (cid:271)ut if it"s for(cid:272)ed out (cid:894)rbcs(cid:895) the(cid:374) it"s (cid:374)ot a(cid:374) a(cid:272)ti(cid:448)e pro(cid:272)ess (cid:894)diapedesis(cid:895). O(cid:374)(cid:272)e they arri(cid:448)e they (cid:449)ill they"ll u(cid:374)dertake phagocytosis: che(cid:373)i(cid:272)al (cid:373)ediators hista(cid:373)i(cid:374)e > released by mast cells, basophils (wbc) Increases permeability, vasodilation and endothelial and platelets. activation: kallikrein-kinin system (bradykinin) > same as histamine but just slower, complement > cascade of activation of proteins, in which the end job is cell lysis or phagocytosis. Takes longer to commence & ends longer too faster but short lived) After 24hrs monocytes become abundant (slower but longer lived in vascular space: neutrophils > monocytes. Plasminogen, which is then converted to its active form plasmin (responsible for fibrin (clot) breakdown): plas(cid:373)i(cid:374)oge(cid:374) (cid:271)i(cid:374)ds to the (cid:272)lot a(cid:374)d is converted to plasmin. Vitamin k is needed for the production of factors: 2, 7, 9, 10. Role of chemical mediators of inflammation histamine, prostaglandin, bradykinin. Histamine > made from mast cells (connective tissue) and basophils (wbc).
