300816 Lecture Notes - Lecture 9: Glomerular Basement Membrane, Type Iii Hypersensitivity, Type I Hypersensitivity
Document Summary
Extends from the nasal orifice to the larynx; which immediately precedes the trachea. Infections are usually viral, with acute inflammation occurring. Acute glomerulonephritis has antigen-antibody complex that are trapped in the glomerular basement membrane. Therefore basement membrane damage can have inflammatory reaction in the kidneys. Natural antibodies can cross react with the antigens in the connective tissues of heart and joints. This can create an inflammatory reaction through all layers of the heart (ie myo-, peri-, endo-cardium). Alveolar inflammation, with the formation of a protein-rich exudate. Affects otherwise healthy adults between 20-50 years of age. Fever can be very high (40), with rigors. As the lung becomes consolidated, the chest signs are dullness to percussion with bronchial breathing. Characteristic patchy distribution, centered on inflamed bronchioles and bronchi with subsequent spread to surrounding alveoli. Most commonly in old age, in infancy and patients with debilitating diseases. With antibiotics and physiotherapy, the inflammation resolves.
