300816 Lecture Notes - Lecture 12: Primitive Cell, Turnover Number, Skeletal Muscle
Document Summary
Process of increase in size resulting from the synthesis of specific tissue components. Multiplicative is increase in cell numbers by mitotic division, and is present in all tissues during embryogenesis. Auxetic is increased size of individual cells, such as seen in skeletal muscle. Accretionary is increase in intercellular tissue components, such as bone and cartilage. Process whereby a cell develops an overt specialised function or morphology that distinguishes it from its parent cell. Occurs through selective expression of genes and these products act to produce a cell with a specialised function. Highly complex process of development of structural shape and form of organs, limbs, facial features etc. from primitive cell masses during embryogenesis. Enables cells or tissues destroyed by injury or disease to be replaced by functionally identical cells. These replacement cells are usually derived from a tissue reservoir of parent stem cells. High regenerative capacity means that lost cells are rapidly replaced by division of stem cells.
