91401 Lecture Notes - Lecture 7: Immunological Synapse, Il-2 Receptor, Zap70
Document Summary
Genetics of the tcr & the immunological synapse 3. T cell interacting with a dendritic cell through the immunological synapse (adhesion molecules, foreign antigen). The immunological synapse *important: adhesion zone: molecules: t cells -lfa1(leukocyte function antigen) apc or. Target cell: icam -1 (intracell. adhes. mol): signalling domain: molecules: tcr, cd3, cd8 signalling: zap70, pkc, lck, secretory domain: molecules: perforin, granzymes, il-2 and other cytokines; note: the donut" structure. Interaction in addition to lfa1 and icam, both cd4 and cd8 positive cells have. Cd2 receptors that interact with lfa-3 on the apc or the target cell. Why an immunological synapse: confinement (prevents neighbouring cells coming into contact with cytotoxic molecules) Molecules released by effector t cells (e. g. cytokines, perforins) are potent: concentration. Clustering of antigens and cognate bcr/tcr: activation. Signal pathways induce gene transcription: exocytosis. Cytokines (e. g. th1: ifn ,th2: il-4, il-13), perforins/granzyme.
