91401 Lecture Notes - Lecture 4: Fragment Antigen-Binding, Fragment Crystallizable Region, Natural Killer Cell
Document Summary
Each b cell clone expresses a unique antibody receptor antibody receptor (b cell receptor bcr) How the unique binding site on an antibody generated: antigen binding occurs in a region called the variable domain" termed vh or. Vl: during b cell development, the gene encoding the heavy or light chain variable regions is generated at random from a selection of gene segments. Vdj recombination of the heavy and light chain variable regions: gene encoding heavy chain: the variable domains are stitched" together from three different gene segments. J: for joining": process relies on recombination activating gene (rag)1 and 2, heavy chain vh is comprised of one v, one d and one j segment. To decrease chances of auto immunity b cells undergo negative selection. Receptor editing: clonal elimination or depletion, clonal inactivation or anergy. Clonal elimination (depletion) and receptor editing: occurs as a response to multivalent self-antigen binding, recombination is done to prevent self-antigen recognition (vdj recombination).
